Computational Approaches for Understanding Human Immune System and Immune-Related Diseases
Intelligent Systems for Molecular Biology (ISMB), 2020
Monday, July 13th, 2020 -- Online
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Session Topics:
- The role of age, sex, and genetics in shaping the immune system
- Single-cell profiling of human immune cells
- Methods for single-cell analyses and integration
- Epigenomic characterization of immune cells in health and disease
- Discovery of immune cell epitopes
- Immunometabolism
- Computational modeling of the tumor immune microenvironment
- Gene dysregulation in autoimmune diseases
Theme
Dysfunctions in the immune system are important contributing factors, if not the driving factors, for a wide range of human diseases. Advances in next generation sequencing techniques are providing us opportunities to closely monitor human immune cells in health and disease, and uncover genomic and epigenomic signatures that can be linked to pathologies. However, the analyses and integration of multi-faceted genomic data are not trivial and require sophisticated computational methods. These methods are developed for data processing and analysis (e.g., imaging, cell sorting, epitope identification, single-cell sequencing), for linking genetic and epigenetic variation to disease susceptibility (GWAS, eQTL, chromatin QTL) and for integrating epigenome, transcriptome and cell abundance measurements from multiple distinct immune cells in the context of immune related diseases such as autoimmune diseases and cancer. As the amount of data collected from individuals to profile their immune systems is increasing, we are encountering a bottleneck to integrate cross-platform data and mine these to test biological hypotheses. This meeting aims to bring together computational scientists who develop methods to effectively analyze single-cell level and bulk measurements from human immune cells in diverse contexts including aging, autoimmune diseases and cancer as well as in the broader context of understanding genetic and epigenetic regulation of gene expression.
Call for contributed talks
We invite you to submit abstracts for short talks (10 mins) for our Systems Immunology session. Please use this link and select the Systems Immunology Special session to submit abstracts by June 5th. Looking forward to hearing about your latest work!
Invited Speakers
| Name | Title | Affiliation |
|---|---|---|
| Bali Pulendran | Violetta I. Horton Prof. of Microbiology and Immunology | Stanford University and Parker Institute (Keynote) |
| John Tsang | Chief and Prof. of Multiscale Systems Biology | NIH / NIAID |
| Kathyrn Miller-Jensen | Associate Prof. of Biomedical Engineering and Molecular, Cellular and Developmental Biology | Yale University |
| Bjoern Peters | Prof. of Computational Biology and Vaccine Discovery | La Jolla Institute for Immunology |
| Jane Skok | Sandra and Edward H. Meyer Prof. of Dept. of Pathology | NYU Langone Health |
| Pandurangan Vijayanand | Associate Prof. of Vaccine Discovery | La Jolla Institute for Immunology; UC San Diego |
| Shuzhao Li | Associate Prof. of Genetics and Genome Sciences | The Jackson Laboratory for Genomic Medicine |
| David Hawkins | Associate Prof. of Genome Sciences and Medical Genetics | University of Washington |
| Duygu Ucar | Associate Prof. of Genetics and Genome Sciences | The Jackson Laboratory for Genomic Medicine (Organizer) |
| Ferhat Ay | Institute Leadership Assistant Prof. of Computational Biology | La Jolla Institute for Immunology; UC San Diego (Organizer) |
Latest schedule is available here.
Organizers
- Ferhat Ay (ferhatay@lji.org) -- http://www.lji.org/faculty-research/labs/ay
- Duygu Ucar (duygu.ucar@jax.org) -- https://www.ucarlab.com/
Other workshops/sessions/conferences
- Jackson Laboratory -- Systems Immunology -- Sep 2-3, 2020, Virtual event
- ISMB 2018 - 3D Genome -- http://3dgenome.lji.org
- GLBIO 2017 - 3D Genome -- https://3dgenome.discovery.wisc.edu/
Sponsors
Please direct questions to Ferhat Ay (ferhatay@lji.org).